Sequence Detail

ID/Version

Q9Z0I6 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Schlafen family member 2 {ECO:0000305}; Short=Schlafen-2 {ECO:0000303|PubMed:9846487};

Provider

SWISS-PROT

Sequence

Polypeptide 378 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slfn2	schlafen 2	12	97	3	6

Sequence references in MGI

J:51308 Schwarz DA, et al., Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity. 1998 Nov;9(5):657-68
J:154883 Katsoulidis E, et al., Role of Schlafen 2 (SLFN2) in the generation of interferon alpha-induced growth inhibitory responses. J Biol Chem. 2009 Sep 11;284(37):25051-64
J:158985 Berger M, et al., An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat Immunol. 2010 Apr;11(4):335-43
J:247113 Omar I, et al., Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis. Immunology. 2017 Nov;152(3):484-493
J:267883 Lilue J, et al., Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci. Nat Genet. 2018 Nov;50(11):1574-1583
J:314967 Yue T, et al., SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity. Science. 2021 May 14;372(6543)
J:319575 Omar I, et al., Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence. Oncotarget. 2016 Jun 28;7(26):39396-39407