Sequence Detail

ID/Version

Q9Z0J0 Q3UB23 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=NPC intracellular cholesterol transporter 2 {ECO:0000312|MGI:MGI:1915213};AltName: Full=Epididymal secretory protein E1; Short=mE1 {ECO:0000303|PubMed:10863096};AltName: Full=Niemann Pick type C2 protein homolog;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 149 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Npc2	NPC intracellular cholesterol transporter 2	33	99	4	22

Sequence references in MGI

J:62993 Nakamura Y, et al., Primary structure, genomic organization and expression of the major secretory protein of murine epididymis, ME1. Gene. 2000 Jun 13;251(1):55-62
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:127209 Liou HL, et al., NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols. J Biol Chem. 2006 Dec 1;281(48):36710-23
J:192648 Yamanashi Y, et al., NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport. Gastroenterology. 2011 May;140(5):1664-74
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89