Sequence Detail

ID/Version

Q9Z0J7 Q6NX63 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Growth/differentiation factor 15 {ECO:0000303|PubMed:10779363}; Short=GDF-15 {ECO:0000303|PubMed:10779363};AltName: Full=Macrophage inhibitory cytokine 1 {ECO:0000303|PubMed:23468844}; Short=MIC-1 {ECO:0000303|PubMed:23468844

Provider

SWISS-PROT

Sequence

Polypeptide 303 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gdf15	growth differentiation factor 15	50	103	2	24

Sequence references in MGI

J:61788 Hsiao EC, et al., Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol. 2000 May;20(10):3742-51
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:154446 Strelau J, et al., Progressive postnatal motoneuron loss in mice lacking GDF-15. J Neurosci. 2009 Oct 28;29(43):13640-8
J:171576 Kempf T, et al., GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med. 2011 May;17(5):581-8
J:197174 Tsai VW, et al., TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator. PLoS One. 2013;8(2):e55174
J:246122 Low JK, et al., First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-beta Superfamily Cytokine, MIC-1/GDF15. PLoS One. 2017;12(1):e0168416
J:246965 Chung HK, et al., Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017 Jan 02;216(1):149-165
J:251850 Emmerson PJ, et al., The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL. Nat Med. 2017 Oct;23(10):1215-1219
J:251855 Mullican SE, et al., GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates. Nat Med. 2017 Oct;23(10):1150-1157
J:251981 Yang L, et al., GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand. Nat Med. 2017 Oct;23(10):1158-1166
J:254140 Hsu JY, et al., Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature. 2017 Oct 12;550(7675):255-259
J:261053 Wang T, et al., GDF15 is a heart-derived hormone that regulates body growth. EMBO Mol Med. 2017 Aug;9(8):1150-1164
J:264354 Tran T, et al., GDF15 deficiency promotes high fat diet-induced obesity in mice. PLoS One. 2018;13(8):e0201584
J:283184 Xiong Y, et al., Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys. Sci Transl Med. 2017 Oct 18;9(412)
J:285776 Ost M, et al., Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep. 2020 Mar 4;21(3):e48804
J:292147 Coll AP, et al., GDF15 mediates the effects of metformin on body weight and energy balance. Nature. 2020 Feb;578(7795):444-448
J:292414 Johnen H, et al., Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat Med. 2007 Nov;13(11):1333-40
J:298668 Worth AA, et al., The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling. Elife. 2020 Jul 29;9:e55164
J:300248 Breen DM, et al., GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates. Cell Metab. 2020 Dec 1;32(6):938-950.e6
J:304627 Klein AB, et al., Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise. Nat Commun. 2021 Feb 15;12(1):1041
J:316128 Sabatini PV, et al., GFRAL-expressing neurons suppress food intake via aversive pathways. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2021357118
J:325215 Suriben R, et al., Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice. Nat Med. 2020 Aug;26(8):1264-1270
J:328108 Klein AB, et al., The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance. Cell Rep. 2022 Aug 23;40(8):111258
J:332012 Xie B, et al., Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice. iScience. 2022 Dec 22;25(12):105569
J:338885 Kim J, et al., TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response. Nat Metab. 2021 Mar;3(3):410-427
J:340165 Wang D, et al., GDF15 promotes weight loss by enhancing energy expenditure in muscle. Nature. 2023 Jul;619(7968):143-150
J:341053 Breit SN, et al., GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway. Cell Metab. 2023 Aug 8;35(8):1341-1355.e3
J:341091 Florsheim EB, et al., Immune sensing of food allergens promotes avoidance behaviour. Nature. 2023 Aug;620(7974):643-650
J:342573 Lu JF, et al., Camptothecin effectively treats obesity in mice through GDF15 induction. PLoS Biol. 2022 Feb;20(2):e3001517
J:344181 Fejzo M, et al., GDF15 linked to maternal risk of nausea and vomiting during pregnancy. Nature. 2023 Dec 13;
J:345047 Day EA, et al., Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss. Nat Metab. 2019 Dec;1(12):1202-1208
J:347515 Lu JF, et al., GDF15 is a major determinant of ketogenic diet-induced weight loss. Cell Metab. 2023 Dec 5;35(12):2165-2182.e7