Sequence Detail

ID/Version

Q9Z0W1 Q8CFT3 (UniProt | EBI)

Last sequence update: 2019-07-03
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Tumor necrosis factor receptor superfamily member 16;AltName: Full=Low affinity neurotrophin receptor p75NTR {ECO:0000303|PubMed:9857182};AltName: Full=Low-affinity nerve growth factor receptor; Short=NGF receptor;AltName: Full=Low-a

Provider

SWISS-PROT

Sequence

Polypeptide 427 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	110	192	4	29

Sequence references in MGI

J:43748 Lee KF, et al., Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell. 1992 May 29;69(5):737-49
J:70533 Tuffereau C, et al., Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus. EMBO J. 1998 Dec 15;17(24):7250-9
J:71955 von Schack D, et al., Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat Neurosci. 2001 Oct;4(10):977-8
J:183530 Baeza-Raja B, et al., p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5838-43
J:199564 Baeza-Raja B, et al., p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci. 2013 Jun 19;33(25):10221-34
J:214739 Glerup S, et al., SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014 Jun 4;82(5):1074-87
J:224729 Nakaya N, et al., Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth. J Biol Chem. 2012 Oct 26;287(44):37171-84
J:260288 Deinhardt K, et al., Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal. 2011 Dec 6;4(202):ra82
J:267910 Giza JI, et al., The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. 2018 Jul 11;99(1):163-178.e6
J:274852 Glerup S, et al., SorCS2 is required for BDNF-dependent plasticity in the hippocampus. Mol Psychiatry. 2016 Dec;21(12):1740-1751