Sequence Detail

ID/Version

Q9Z1P4 Q3V1L2 (UniProt | EBI)

Last sequence update: 2009-07-28
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Leucine-rich repeat-containing G-protein coupled receptor 5;AltName: Full=G-protein coupled receptor 49;AltName: Full=Orphan G-protein coupled receptor FEX {ECO:0000303|PubMed:9920770};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 907 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lgr5	leucine rich repeat containing G protein coupled receptor 5	22	157	2	26

Sequence references in MGI

J:51995 Hermey G, et al., Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouse. Biochem Biophys Res Commun. 1999 Jan 8;254(1):273-9
J:94196 Morita H, et al., Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension. Mol Cell Biol. 2004 Nov;24(22):9736-43
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:127123 Barker N, et al., Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007 Oct 25;449(7165):1003-7
J:143598 Jaks V, et al., Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet. 2008 Nov;40(11):1291-9
J:174842 de Lau W, et al., Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011 Aug 18;476(7360):293-7
J:184685 Wilson CH, et al., Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J. 2012;31(11):2486-97
J:262420 Szenker-Ravi E, et al., RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. Nature. 2018 May;557(7706):564-569