Sequence Detail

ID/Version

Q9Z1S8 Q9R1X3 (UniProt | EBI)

Last sequence update: 2004-04-13
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=GRB2-associated-binding protein 2;AltName: Full=GRB2-associated binder 2;AltName: Full=Growth factor receptor bound protein 2-associated protein 2;AltName: Full=PH domain-containing adaptor molecule p97;

Provider

SWISS-PROT

Sequence

Polypeptide 665 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gab2	growth factor receptor bound protein 2-associated protein 2	31	98	3	18

Sequence references in MGI

J:51807 Gu H, et al., Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol Cell. 1998 Dec;2(6):729-40
J:53418 Nishida K, et al., Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood. 1999 Mar 15;93(6):1809-16
J:70424 Gu H, et al., Essential role for Gab2 in the allergic response. Nature. 2001 Jul 12;412(6843):186-90
J:97515 Wada T, et al., The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med. 2005 Apr;11(4):394-9
J:129191 Yu M, et al., Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. J Immunol. 2006 Feb 15;176(4):2421-9
J:145408 Zhang Y, et al., Abnormal hematopoiesis in Gab2 mutant mice. Blood. 2007 Jul 1;110(1):116-24
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:334006 Choi HK, et al., Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. Cell Res. 2013 Apr;23(4):524-36