Sequence Detail

ID/Version

Q9Z2D3 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Gasdermin-E {ECO:0000250|UniProtKB:O60443};AltName: Full=Non-syndromic hearing impairment protein 5 homolog {ECO:0000305};Contains: RecName: Full=Gasdermin-E, N-terminal {ECO:0000250|UniProtKB:O60443}; Short=GSDME-NT {ECO:0000250|

Provider

SWISS-PROT

Sequence

Polypeptide 512 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gsdme	gasdermin E	37	101	4	15

Sequence references in MGI

J:50172 Van Laer L, et al., Nonsyndromic hearing impairment is associated with a mutation in DFNA5. Nat Genet. 1998 Oct;20(2):194-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:241308 Rogers C, et al., Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. Nat Commun. 2017 Jan 03;8:14128
J:250434 Wang Y, et al., Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 2017 Jul 6;547(7661):99-103
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:292705 Zhang Z, et al., Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature. 2020 Mar;579(7799):415-420