Sequence Detail

ID/Version

Q9Z2I4 A0A1L1SU85 D3Z4M6 (UniProt | EBI)

Last sequence update: 2024-01-24
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Roundabout homolog 3;AltName: Full=Retinoblastoma-inhibiting gene 1 protein; Short=Rig-1;AltName: Full=Roundabout guidance receptor 3 {ECO:0000312|MGI:MGI:1343102};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1402 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Robo3	roundabout guidance receptor 3	13	151	4	10

Sequence references in MGI

J:53337 Yuan SS, et al., Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. Dev Biol. 1999 Mar 1;207(1):62-75
J:87380 Camurri L, et al., Rig-1 a new member of Robo family genes exhibits distinct pattern of expression during mouse development. Gene Expr Patterns. 2004 Jan;4(1):99-103
J:89438 Sabatier C, et al., The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell. 2004 Apr 16;117(2):157-69
J:145298 Chen Z, et al., Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion. Neuron. 2008 May 8;58(3):325-32
J:218606 Zelina P, et al., Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution. Neuron. 2014 Dec 17;84(6):1258-72
J:227045 Jaworski A, et al., Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2. Science. 2015 Nov 20;350(6263):961-5
J:276416 Zhuang M, et al., The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression. Nucleic Acids Res. 2019 May 21;47(9):4765-4777
J:286386 Pak JS, et al., NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance. Nat Commun. 2020 Mar 20;11(1):1489