Sequence Detail

ID/Version

Q9Z2R9 Q9CTP5 Q8K123 Q69ZK8 Q9D601 Q8C024 Q2TA96 (UniProt | EBI)

Last sequence update: 2011-04-05
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 1; EC=2.7.11.1 {ECO:0000269|PubMed:12767237, ECO:0000305|PubMed:11726526, ECO:0000305|PubMed:9822714};AltName: Full=Heme-controlled repressor; Short=HCR;AltName: Full=He

Provider

SWISS-PROT

Sequence

Polypeptide 619 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eif2ak1	eukaryotic translation initiation factor 2 alpha kinase 1	61	98	3	12

Sequence references in MGI

J:51221 Berlanga JJ, et al., Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells. J Biol Chem. 1998 Nov 27;273(48):32340-6
J:85896 Han AP, et al., Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J. 2001 Dec 3;20(23):6909-18
J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99200 Han AP, et al., Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia. J Clin Invest. 2005 Jun 1;115(6):1562-1570
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113887 Crosby JS, et al., Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase. Blood. 2000 Nov 1;96(9):3241-8
J:114048 Bauer BN, et al., Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase. Biochemistry. 2001 Sep 25;40(38):11543-51
J:127433 Liu S, et al., The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. J Clin Invest. 2007 Nov;117(11):3296-305
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89