Sequence Detail

ID/Version

Q9Z2V6 Q9JL73 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Histone deacetylase 5; Short=HD5; EC=3.5.1.98;AltName: Full=Histone deacetylase mHDA1;

Provider

SWISS-PROT

Sequence

Polypeptide 1113 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hdac5	histone deacetylase 5	100	108	3	11

Sequence references in MGI

J:52197 Verdel A, et al., Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999 Jan 22;274(4):2440-5
J:64684 Kao HY, et al., Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000 Jan 1;14(1):55-66
J:67665 Zhang CL, et al., Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem. 2001 Jan 5;276(1):35-9
J:95385 Cao D, et al., Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005 Jan;25(1):364-76
J:114106 Kurtev V, et al., Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem. 2004 Jun 4;279(23):24834-43
J:121892 Berdeaux R, et al., SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med. 2007 May;13(5):597-603
J:138970 Martini JS, et al., Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12457-62
J:189792 Rui J, et al., Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation. J Immunol. 2012 Aug 1;189(3):1380-90
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89