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Name
ID 		C57BL/6NCrl-Tlr7em2Anu
MGI:7284943
Phenotype annotations related to immune system
Darker colors indicate more annotations
Mouse Phenotypes
abnormal B cell physiology
abnormal macrophage physiology
abnormal mature B cell morphology
abnormal Peyer's patch morphology
abnormal plasmacytoid dendritic cell physiology
decreased B cell apoptosis
decreased B cell proliferation
decreased leukocyte cell number
decreased marginal zone B cell number
enlarged spleen
glomerulonephritis
increased anti-double stranded DNA antibody level
increased anti-nuclear antigen antibody level
increased anti-single stranded DNA antibody level
increased autoantibody level
increased B cell number
increased CD4-positive, alpha-beta T cell number
increased circulating interferon-gamma level
increased circulating interleukin-6 level
increased circulating interleukin-10 level
increased circulating tumor necrosis factor level
increased effector memory CD4-positive, alpha-beta T cell number
increased germinal center B cell number
increased inflammatory response
increased plasma cell number
increased spleen germinal center number
increased susceptibility to systemic lupus erythematosus
increased T follicular helper cell number
liver inflammation
lung inflammation
lymph node inflammation
pancreas inflammation
salivary gland inflammation
spleen hyperplasia
Availability Mouse Genotype
Tlr7em2Anu/Tlr7+
Tlr7em2Anu/Tlr7em2Anu
Tlr7em2Anu/Y